Alexander R Stanton

Project: Cellular growth is regulated in part by the translocation of ERK 1/2 to the nucleus. Aberrant regulation of the kinase signaling pathway that controls translocation leads to excessive cell growth/proliferation: cancer. A potential therapeutic, UO126, inhibits ERK preventing cell growth/proliferation. My research was testing the efficacy of this therapeutic.

​

Involvement: Commuting from Paradise, CA to Berkeley, CA (~3 hours) on available weekends from Nov. 2007 to Apr. 2008, staying the weekend, and spending the days running supervised experiments. 

​

Presentation: To conclude my research done with Gray Labs, I constructed a Powerpoint presentation compiling background information, experimental techniques, and data. This presentation was given in seminar format to a panel of science teachers as well as a handful of fellow students.



*Videos at the right: Serum starved cells transfected with GFP-ERK1/2 after exposure to growth factors. The nuclear translocation of ERK1/2 can be observed in the increasing fluorescence of nuclei.